Comparative Hemodynamic Effects of Hypotension Induced by Nitroprusside and a Nitroprusside-Trimetaphan Mixture in Dogs
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چکیده
منابع مشابه
Metabolic effects of induced hypotension with trimetaphan and sodium nitroprusside.
In two groups of patients undergoing induced hypotension with sodium nitroprusside or trimetaphan blood concentrations of lactate, pyruvate and standard bicarbonate did not differ significantly between the groups. In the nine patients who received trimetaphan there was a progressive, but statistically non-significant, decrease in mean lactate. Nitroprusside (15 patients) was associated with a s...
متن کاملIntracranial pressure changes in neurosurgical patients during hypotension induced with sodium nitroprusside or trimetaphan.
Intracranial pressure has been measured in 45 patients undergoing neurosurgery during the induction of deliberate hypotension using either sodium nitroprusside or trimetaphan. A statistically significant increase in intracranial pressure (ICP) occurred during the early stages of the infusion of nitroprusside in normocapnic patients. A non-significant increase in ICP was obtained in hypocapnic p...
متن کاملCerebral blood flow distribution during induced hypotension with haemorrhage, trimetaphan or nitroprusside in rats.
Local cerebral blood flow (CBF) during three types of profound hypotension were compared using the quantitative autoradiographic [14]-C iodo-antipyrine method. Rats were rendered hypotensive to a mean arterial pressure of 30 mm Hg for 30 min by haemorrhage, trimetaphan or nitroprusside during 0.8% halothane anaesthesia. During haemorrhagic hypotension, mean local CBF was reduced significantly i...
متن کاملCyanide toxicity following nitroprusside induced hypotension.
Several recently reported deaths following the use of sodium nitroprusside have been attributed to the accumulation of the nitroprusside metabolite, cyanide. In this study, brief nitroprusside infusions (mean = 36 minutes) were administered in currently recommended doses during intracranial surgery. The peak blood cyanide following the infusions was 65.2 +/- 17.5 microgram per cent (mean +/- SE...
متن کاملElectrical activity of the cerebral cortex during induced hypotension in man. A comparison of sodium nitroprusside and trimetaphan.
During the routine use of controlled hypotension the electroencephalogram (EEG) and mean arterial pressure (MAP) were monitored in 20 normotensive patients (younger than 70 years-of-age) receiving either trimetaphan (TMP) or sodium nitroprusside (SNP). The reduction in MAP was quicker and greater with SNP. Significant differences in EEG voltage between the two agents were seen in the range 55-4...
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ژورنال
عنوان ژورنال: The Showa University Journal of Medical Sciences
سال: 1997
ISSN: 0915-6380,2185-0968
DOI: 10.15369/sujms1989.9.127